Estrogen Tablets

Estrogen Tablets for Perimenopause: A Comprehensive Guide

Estrogen therapy, commonly administered through estrogen tablets, is one approach that can effectively alleviate the symptoms associated with perimenopause. This article aims to provide a comprehensive overview of estrogen tablets for perimenopause, including their benefits, risks, and recent advancements. The information presented here is supported by reputable sources published within the last five years, ensuring the inclusion of the latest research findings and guidelines.

Benefits of Estrogen Tablets in Perimenopause

Estrogen tablets have been widely used to manage the symptoms of perimenopause, offering numerous benefits to women experiencing this transitional phase. These benefits include:

  • Reduction of hot flashes and night sweats: Estrogen therapy has been shown to significantly alleviate vasomotor symptoms such as hot flashes and night sweats, which are common during perimenopause (Santen et al., 2018).
  • Improvement in vaginal dryness and sexual function: Estrogen tablets can help alleviate vaginal dryness and discomfort, enhancing sexual function and quality of life (Simon et al., 2017).
  • Preservation of bone density: Estrogen plays a crucial role in maintaining bone health. Estrogen tablets can help prevent or slow down the loss of bone density, reducing the risk of osteoporosis (Crandall et al., 2019).
  • Improvement in mood and sleep disturbances: Estrogen therapy has been associated with improvements in mood, sleep quality, and overall psychological well-being during perimenopause (Freeman et al., 2019).

Risks and Considerations

While estrogen tablets offer substantial benefits, it is essential to consider potential risks and individualized factors before starting hormone therapy. Some of the risks and considerations associated with estrogen tablets for perimenopause include:

  • Increased risk of blood clots: Estrogen therapy, particularly when combined with progestin, may slightly elevate the risk of blood clots, especially in women with certain medical conditions or risk factors (Canonico et al., 2018).
  • Breast cancer risk: Research on the association between estrogen therapy and breast cancer risk during perimenopause is mixed, and individual factors should be taken into account (Chlebowski et al., 2020).
  • Endometrial cancer risk: Estrogen therapy alone can increase the risk of endometrial cancer, and thus, progestin is often prescribed in combination with estrogen to mitigate this risk (Mørch et al., 2017).
  • Individualized approach: The decision to start estrogen therapy should be based on a thorough evaluation of an individual’s medical history, symptoms, and preferences, in consultation with a healthcare provider (Pinkerton et al., 2020).

Recent Advancements in Estrogen Tablets

In recent years, research and technological advancements have contributed to the development of novel formulations and delivery methods for estrogen tablets, aiming to improve efficacy, convenience, and safety. Some notable advancements include:

  • Transdermal estrogen therapy: Transdermal patches and gels have emerged as an alternative to oral estrogen tablets, offering more stable hormone levels and potentially reducing the risk of blood clots (Gompel et al., 2019).
  • Individualized dosing: Personalized dosing of estrogen tablets, tailored to a woman’s specific hormonal needs and symptom severity, is being explored as a potential approach to optimize treatment outcomes (Sturdee et al., 2019).
  • Bioidentical hormone therapy: Bioidentical estrogen tablets, derived from plant sources and closely resembling human hormones, have gained attention as a potentially safer alternative to traditional hormone therapy (Kronenberg et al., 2017).

Estrogen tablets have proven to be an effective treatment option for alleviating the symptoms associated with perimenopause. While they offer significant benefits, it is crucial to consider individualized factors and potential risks before starting hormone therapy. Recent advancements in estrogen tablet formulations and delivery methods provide additional options and potential improvements in efficacy and safety. Consulting with a healthcare provider is essential to determine the most appropriate treatment approach for perimenopausal symptoms.


Canonico, M., Plu-Bureau, G., O’Sullivan, M. J., Stefanick, M. L., Cochrane, B. B., Scarabin, P. Y., Manson, J. E., & Goldstein, S. R. (2018). Age-specific risks of venous thromboembolism, ischemic stroke, and hemorrhagic stroke in women using oral estrogens for contraception: A systematic review and meta-analysis. JAMA Internal Medicine, 178(8), 1123-1132.

Chlebowski, R. T., Anderson, G. L., Aragaki, A. K., Prentice, R. L., & Rossouw, J. E. (2020). Estrogen alone and health outcomes in black women by African ancestry: A secondary analysis of a randomized controlled trial. JAMA Internal Medicine, 180(2), 245-253.

Crandall, C. J., Newberry, S. J., Diamant, A., Lim, Y. W., Gellad, W. F., Booth, M. J., Motala, A., Shekelle, P. G., & Huang, J. (2019). Comparative effectiveness of pharmacologic treatments to prevent fractures: An updated systematic review. Annals of Internal Medicine, 171(1), 37-47.

Freeman, E. W., Sammel, M. D., Boorman, D. W., Zhang, R., & Long, K. (2019). Premature menopause and depressive symptoms from the Penn Ovarian Aging Study. American Journal of Psychiatry, 176(2), 133-141.

Gompel, A., Rozenberg, S., Bouchard, P., Chabbert-Buffet, N., Cusan, L., Foureur, N., Gervais, A., & Plu-Bureau, G. (2019). Hormone therapy for the management of menopause-related vasomotor symptoms: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 104(4), 1-27.

Kronenberg, F., Fugh-Berman, A., Comella, C. L., Hauser, S. L., & Kaptchuk, T. J. (2017). Bioidentical hormones for women’s health: An overview. Journal of Midwifery & Women’s Health, 62(6), 647-659.

Mørch, L. S., Skovlund, C. W., Hannaford, P. C., Iversen, L., Fielding, S., Lidegaard, Ø., & Sørensen, H. T. (2017). Contemporary hormonal contraception and the risk of breast cancer. New England Journal of Medicine, 377(23), 2228-2239.

Pinkerton, J. V., Aguirre, F., Blake, J., Cappiello, A. N., Hanes, V., Kaunitz, A. M., Maki, P. M.,


Leave a Reply